Question

The protein p53 is reported to be present in a cell at a population of 6 molecules in a cell whose volume is 10-12 L. Assuming the entire cell is accessible to p53, what is the intracellular concentration of p53? O 10-15 M. O 10-11 M O 10-14 M O 10-13 M O 10-12 M

Answer 1

you can also simply divide the number of molecules by the number of molecules in a mole to obtain the never of moles

for ps3 protein; wt. of I molecule a 43.7k Da 1 Da = lamu 1.661x15249 & 43. 7 kDa - 7. 26% 10 g There are 6 protein molemles in a cell & wt. of protein in a cell = 6x7.26 K 15209 - 4356 *10 g Now, I mole of any entity has 6.022% 16²3 entities 2. Wt of I mole p53 = 6.0228 1623 x 7.26 21020 = 43.72 x 103 g & Mole ewt. of p53 = 43.72 x 163 g/onof Now & moles of p53 in cell = wt of p53 in cell Mol. wt of 853 43.56x102 43.72 x 163 0.9968 10-2 moles i Molarity = moles - 0.996x16 23 Volume 12 10-12 = 0.996x10" a 1x100M. Option B.