Question

A “knock-out” of the cyclin-cdk inhibitor p19 was generated in mice. What this means is that the gene for p19 was functionally removed. As such, the mouse was p19-/- or genetically negative for p19 and none of its cells have the p19 protein being made. They also removed the cdk4 (cyclin dependent kinase-4) in some of the mice. On a tissue level, tumors were formed in the pituitary anterior lobe, and other tissues.

What would you expect to happen to each of the following in the cells of the p19-/- mouse:

1. pRB phosphorylation?

2. Rate of cell proliferation?

Answer 1

Abra L9 aeime