Question

If Vascular Endothelial Growth factor (VEGF) is knocked out in mouse embryos which of the following...

If Vascular Endothelial Growth factor (VEGF) is knocked out in mouse embryos which of the following is most likely responsible for the phenotype?

A. Hemangioblasts will not differentiate into angioblasts

B. Blood vessles will not recruit pericytes

C. Cardiogenic mesoderm will not be specified

D. Hemangioblasts will not be specified in the splanchnic mesoderm

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Answer #1

A is the correct answer that is if vascular endothelial growth factor is knocked out in mouse embryos then hemangioblast will not differentiate into angioblast.
VEGF is responsible for blood vessel construction and angioblast are formed by the signal of VEGF to differentiate into angioblast.
B is wrong because recruitment of pericyte is not regulated by VEGF.
C and D are wrong because cardiogenic mosoderm and splanchnic mesoderm specification is not regulated by the VEGF.

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