Question

Explain the histology of the thyroid gland, how thyroid hormone is synthesized in the epithelial cells of the follicle, such as the iodine trap, the hypothalamus-adenohypohysis-thyroid gland axis and negative feedback regulation, the regulation using iodine, the intracellular signaling pathways within the adenohypophysis and the thyroid gland, autoregulation of thyroid hormone production, factors regulating thyroid hormone levels, actions of thyroid hormones, mechanism of action of thyroid hormone (TRE-receptor interaction, coactivators, corepressors), major genes whose expression is changed (e.g., Na+/K+-ATPase), the major actions of thyroid hormone across major organ systems (e.g,  nervous, CV, pulmonary, renal).

Answer 1