What type of cell death is most often induced in cancer cells by radiation and chemotherapy drugs? Why is this? (ie- which factor is often missing in cancer cells?)
Chemotherapy is used to kill the cancerous cells and reduce the tumors. It is used to destroy the cell division control center. Chemotherapy mainly targets the fast dividing cells and we know that the cancerous cells divide rapidly. So it leads to apoptosis of cancer cells.
The reasons behind uncontrolled growth of cancerous cells are-
-Lack of contact inhibition in which a cell stops to divide when come in contact with adjacent cells.
-Due to presence of telomerase enzyme.
- lack of tumor protein p53 which is required at checkpoint.
Thanks.
What type of cell death is most often induced in cancer cells by radiation and chemotherapy...
What characteristic makes cancer cells susceptible for radiation/chemotherapy?
Why might inhibition of LDH in cancer cells lead to cancer cell death? Explain why conjugating an LDH inhibitor to glucose leads to preferential targeting of cancer cells?
A. Cancer cells often have acquired mutations that disrupt their ability to undergo programmed cell death. Name three (3) mutations (loss of function or gain of function) in the RTK-PI3 kinase-AKT pathway that would lead to the survival pathway being “always on”. And of course, for each, explain your reasoning.
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Question 5: Signal Transduction A. Cancer cells often have acquired mutations that disrupt their ability to undergo programmed cell death. Name three (3) mutations (loss of function or gain of function) in the RTK-PI3 kinase-AKT pathway that would lead to the survival pathway being “always on”. And of course, for each, explain your reasoning. B. There is a phosphatase called PTEN that dephosphorylates phosphorylated inositol phospholipid (PIP3). Would a loss of function in PTEN cause cells to undergo programmed cell...
Cancer is Uncontrolled Mitosis. Cells that no longer respond properly to cell cycle controls often undergo unrestrained cell division forming abnormal tissues called tumors. If these tumor cells stay within the abnormal tissue, then they are deemed benign and may not harm the individual. However, if the tumor cells invade neighboring tissues and spread to other areas of the body where they can form new tumors, then this type of tumor is called malignant and can adversely affect the affected...
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DNA replication is checked G1 for accuracy Cells no longer divide GO DNA is copied or replicated Cells synthesize proteins G1 needed for the process of mitosis Cell doing its normal 'job GO 30 Crossing over between non Meiosis sister chromosomes Spindle formation complete Prophase I Nuclear membrane reforms Metaphase Chromosomes line up at Metaphase midline Spindle fibers shorten Telophase 13. Cell |Туре Normal Mitotic Index C A E 3% 5% 8% 12% 15%...