epirubicin is an example of an intercalating anticancer agent. To which family of compounds do these...
epirubicin is an example of an intercalating anticancer agent. To which family of compounds do these structures belong? How many and which rings of the tetracyclic system are involved in the intercalation? What role does the ammonium ion play in the molecule's mode of action?
Homework Answers
Answer for part 1 of question.
The structure of intercalating anticancer agents including epirubicin comprises of 4 cyclic rings (tetracyclic ring system), which are six membered. They also contain one sugar substituent. The family of compounds to which such structures belong are called Anthracyclines.
Answer for part 2 of question.
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Answer for part 3 of question
The phosphate ion present on the backbone of DNA is negatively charged where as the ammonium ion present in the intercalating cancer agent is positively charged. Due to the opposite charges of the two ions, a strong ionic is formed between the two groups. Hence, the molecule gets locked in position.
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epirubicin is an example of an intercalating anticancer agent.
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