Question

Which of the following best describes the mechanism of action of bleomycin? (select all that apply)

It intercalates in DNA via the thiazole rings, binds iron ions that cause the production of peroxide radicals that break DNA strands

It forms a complex with iron that causes the production of iron oxides, which inactivate phosphorylated protein kinases

It covalently attaches to topoisomerases, inhibiting their activity

It binds NADPH and reduces some intermediates in the biosynthesis of nucleic acids

Answer 1