Question

Select any/all answers

1. Latent TGFβ is converted to mature TGFβ by
   1. dephosphorylation
   2. phosphorylation
   3. proteolysis
   4. translocation
   5. none of the above
   6. all of the above

2 A loss-of-function mutation in which of the following would inhibit TGFβ signaling?

1. I-Smad
2. R-Smad
3. Ski
4. SnoN
5. all of the above

Answer 1

1. Answer

c. Proteolysis

By proteolytic cleavage, transforming growth factors are released. The latent complex consists of mature TGF and interactions release these mature TGF. TGF regulates cell development and growth.

2. Answer

b. R-Smad

Due to mutations R-Smad  loses its function and inhibit TGF

R-Smad molecules are proteins. They are the main signal transducers for receptors of TGF