The antibacterial drug sulfathiazole is an acid and has a pKa = 7.4. If a plasma sample (pH =7.4) contains 20 mg/L of sulfathiazole, what is the approximate concentration (mg/L) in saliva (pH =8.4) at the same time?
The antibacterial drug sulfathiazole is an acid and has a pKa = 7.4. If a plasma...
You want to achieve a particular plasma concentration of a drug of approximately 81 mg/L in a 70 kg adult male. You know that the total volume of distribution for this drug is ~9L. What dose of drug should you give? (Choose the closest approximate value.) 5670 mg 729 mg correct 10 mg 9 mg In order to achieve the same plasma concentration of the above drug in an adult male who is obese (weighing 125 kg) but otherwise healthy,...
1. Blood is maintained at a pH of 7.4 by the primary buffers in the plasma and secondary buffers in the erythrocytes. The plasma contains carbonic acid/bicarbonate as one of its primary buffers. The pK for this buffer system is 6.3 H2CO3 <=> H+ + HCO3- What is the ratio of bicarbonate to carbonic acid in normal blood plasma?
4. Uric acid has a pKa of 5.35 at 37o C in the urine and a functional pKa of 5.75 in blood plasma. Its anion, urate, has a solubility of about 20X that of uric acid. Uric acid calculi (stones) can form in the body and create very painful symptoms for patients. The normal urine pH is 4.8-7.4 with an average of 5.9. The normal pH of blood is 7.35-7.45. If a patient's blood pH was measured to be 7.42...
Let x be a random variable that represents the pH of arterial plasma (i.e., acidity of the blood). For healthy adults, the mean of the x distribution is μ = 7.4.† A new drug for arthritis has been developed. However, it is thought that this drug may change blood pH. A random sample of 31 patients with arthritis took the drug for 3 months. Blood tests showed that x = 8.4 with sample standard deviation s = 2.7. Use a...
Phenobarbital is a weak acid. Its intrinsic solubility is 1g /L. Its pKa is 7.4 and Mol Wt : 232.32 Calculate the pH of the buffer required to prepare a clear homogeneous solution.of phenobarbital 1 g/100 mL.
PART A. Determine the pH of a 9.553 mM weak acid solution that has a pKa of 8.83 PART B. Calculate the pH of a 319 mM weak base solution with a pKb of 9.04. PART C. Determine the pKa of a weak acid solution that has an initial concentration of 0.334 M and a pH of 4.54. Hint: You know the pH of the solution, so you can easily determine x in your ICE table PART D. Calculate the...
1) An acetic acid aqueous solution has a pKa of 4.76 and pH of 3.00. What is the concentration of acetic acid? 2) An experiment requires you to culture mammalian cells in 10 mL of culture medium buffered to a pH of 7.4 with 25 mM HEPES. After the experiment, the pH dropped to 7.0. How many equivalents of acid must have been produced by the cells to have dropped the pH?
What about the pKa values of the R groups of the seven amino acids containing an ionizable R group? Tyr 10.5 Lys 10.5 Arg 12.5 Asp 3.9 Glu 4.1 His 6.0 Cys 8.4 Indicate the approximate net charge of each of these seven R groups at pH 7.4. Indicate the approximate net charge of each of these seven amino acids at pH 7.4. Note: remember the carboxyl and the alpha-amino group in addition to the ionizable (acidic or basic) R...
benzoic acid has PKa of 4.2 and MW 122g/mol. sodium benzoate has MW 144g/mol . a) mixing 50 grams of benzoic acid with 50 grams of sodium benzoate will lead to the same PH as mixing 200 grams of each. How do they differ in buffer capacity?B) could benzoic acid/ benzoate act as a buffer at PH 6.0? why or why not?C) what concentration of benzoic acid and sodium benzoate should be used to prepare a buffer that has a...
QUESTION 4 Predict the plasma concentration (in mg/L) of Drug-A six (6) hours following the administrtion of a 50 mg IV Bolus to a 42 year old subject. Drug A has a half-life of 6 hours and a volume of distribution of 25 liters