z Instructions Question 1 (Q039) In addition to the repair of DNA double-strand breaks, homologous recombination is a mechanism fe generating genetic diversity by swapping segments of parental chromosomes. During which process does swapping occur? DNA replication ODNA repair O meiosis transposition No new data to save. Last checked at 8:05am
Question 12 Which of the following is NOT necessary for homologous recombination to occur? O nucleases O ligase O 3 DNA strand overhangs 5' DNA strand overhangs O a long stretch of sequence similarity
1. Homologous recombination can happen between non-identical DNA sequences. T/F? 2. Homologous recombination can happen in_______ a) meiosis b) mitosis c) both 3. Homologous recombination in meiosis has the main purpose of_____ a) DNA repair b) Creating new chromosomes c) Sealing double-stranded breaks 4. Strand invasion usually happens without enzymatic assistance. T/F? 5. When replication fork runs into a nick, it results in a_______ a) single-stranded break b) double-stranded break 6. The invading end is usually a _______ a) 3'...
Describe how homologous recombination can change DNA sequences by gene conversion vs. how it can cause deletions/insertions.
Which of the following is NOT a function of homologous recombination? Repair of DNA double strand breaks Repairing bulky DNA damage Pairing of homologous chromosomes in meiosis Rescue of collapsed replication forks
Translocations can occur due to: a. Replication slippage b. Homologous recombination c. Heterologous recombination d. Aneuploidy e. Non-disjunction
q39
Question 39 0.35 pts Homologous recombination is an important mechanism in which organisms use a "backup" copy of the DNA as a template to fix double-strand breaks without loss of genetic information. Which of the following is necessary for homologous recombination to occur? telomerase O 3 DNA strand overhangs • a short stretch of sequence similarity no DNA strand overhangs
Explain the general process of homologous recombination and understand that this process only occurs with DNA-based viruses.
Describe how Nucleotide Excision Repair, Homologous Recombination Repair (HRR), and Non-homologous End Joining (NHEJ) are beneficial for repair of damaged DNA. If you could choose between having HRR and NHEJ performed, which would you choose and why?
Haploid yeast cells that preferentially repair double-strand breaks by homologous recombination (rather than by non-homologous end joining) are especially sensitive to agents that cause double-strand breaks in DNA. If the breaks occur in the G1 phase of the cell cycle, most cells will die; however, if the breaks occur in the G2 phase, a much higher fraction of cells survive. Why do you suppose this is?