Question

Epigenetics seems like quite an interesting field of study. Whereas gene-editing is a somewhat taboo subject, do you think that since epigenetics doesn't change the underlying DNA--that there is less or no controversy in doing it?

To me, what is possible with epigenetics is still a whole new world. If you can control transcription, the body is capable of performing much greater tasks. If used in purely a disease treatment/preventative measure, that alone would raise life-expectancy. But used in more "nefarious" methods could it increase muscle cell growth or am I stretching here?

Answer 1

In a human cell, DNA serves as the genetic material. It contains all the information for the proper growth and development of the cell. DNA codes for RNA which contains coding information to specify a protein sequence. A protein is the structural and functional component of a cell. All the cells in the body contain almost identical genome sequence (except for few immune system cells). However, all cells do not express all the genes all the time. Each tissue type expresses a specific set of genes at specific time period i.e. temporal and spatial expression. Such genes are known as tissue-specific genes. These tissue-specific genes are responsible for different structures and functions of different tissues in our body. The tissue-specific gene expression is mediated by epigenetic as well as transcriptional gene regulation.

Yes.
In epigenetic regulation, the underlying DNA sequence is unaltered. Only the access of transcription machinery to particular genes is altered. So, there is no question of transmitting an altered genome to the progeny. Hence, it is more or less acceptable than gene editing methodology.

It is very much likely that people can programme their own epigenome in near future for their nefarious needs. It is highly possible that people can use to increase socially more acceptable physical features such as muscle strength or fairness.