Question

12. Which of the following has a carbohydrate as part of its structure?

A. Platelet activating factor

B. Ganglioside

C. Sphingosine

D. Ceramide

E. Diacylglycerol

13. Celebrex targets specifically:

A. Cyclooxygenase-1

B. Thromboxane Synthase

C. Lipoxygenase

D. Cyclooxygenase-2

E. Phospholipase A2

22. The human genetic disease phenylketonuria (PKU) can result from:

A. Deficiency of protein in the diet

B. Inability to catabolize ketone bodies

C. Inability to synthesize tetrahydrobiopterin

D. Inability to synthesize phenylalanine

E. Production of enzymes that catabolize tyrosine

26. In the biosynthesis of protoporphyrin IX the metal lead inhibits:

A. The activity of aminolevulinic acid (ALA) hydroxylase

B. The synthesis of globin

C. The activity of ALA dehydratase

D. The degradation of porphobilinogen

E. The activity of ALA Synthase

31. Arachidonic acid may be the product of a reaction catalyzed by:

A. Diacylglycerol Kinase

B. Cyclooxygenase

C. Phospholipase D

D. Thromboxane Synthase

E. Phospholipase A2

Answer 1

Answers

12. Option B

Explanation:Gangliosides is a glycophingolipid that contains N- acetylneurominic acid (as a part of carbohydrate) . It is acidic and important in growth and differentiation of tissue.

13. Option D

Explanation: It is used in the form of drug celecoxib. This pathway is to inhibit COX-2 (cycloxygenase-2

22. Option C

Explanation: Hydroxylase is responsible for the conversion of phenylalanine to other compounds. But hydrolase requires cofactor to function. Thus Tetrahydrobiopterin is that cofactor

26. Option C

Explanation: protoporphyrine IX or lead poisoning enzyme in heme bio- aynthetic pathway inhibited by ALA dehydratase and ferrochelatase.

31. Option E

Explanation: PLA -2 (phospholipase A2) is a family of enzyme that catalyse the phospatidyl cholinehydrolysis and release arachadonic acid and lysophospholipids

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