Question

Select all the metabolites that NEGATIVELY regulate Glycolysis.

Group of answer choices

Glucose-6-Phosphate

Citrate

Fructose-2,6-bisphosphate

ATP

2-

What are all the metabolites that POSITIVELY regulate Gluconeogeneis?

Group of answer choices

Fructose-2,6-bisphosphate

Acetyl CoA

Citrate

AMP

Answer 1

Ans-1 - In glycolysis three major steps are regulated which are catalyzed by the hexokinase or glucokinase, phosphofructokinase, and pyruvate kinase. Phosphofructokinase is an allosteric enzyme and it is negatively regulated by the ATP and Citrate, a product of cellular respiration. If there are high ATP to ADP ratio, the glycolysis is inhibited. Glucose is phosphorylated into glucose 6 phosphate by the hexokinase enzyme which is negatively regulated by its own product. So the negative regulators of the glycolysis are citrate, ATP and Glucose 6 phosphate

Ans -2 - Citrate and Acetyl CoA are the positive regulators of the gluconeogenesis. The enzymes of the gluconeogenesis are fructose 2,6 bisphosphatase and pyruvate carboxylase. Both of these enzymes are positively regulated by the citrate and acetyl CoA. Acetyl CoA positively regulates pyruvate carboxylase, and citrate positively regulates fructose 2,6 bisphosphatase enzyme.

AMP and Fructose 2,6 phosphate negatively regulate glyconeogenesis.