Question

Prp is a prion protein that leads to Creutzfeldt-Jacob disease in humans. What is different between the normal Prp protein and the abnormal Prp protein.

Select one or more:

a. it induces the refolding of many different types of proteins

b. Alpha helices have re-folded into beta strands with hydrophobic R-groups facing the cytosol

c. it induces other correctly folded Prp proteins to misfold.

d. Its primary structure is altered so that there are more hydrophobic R-groups facing the cytosol

Answer 1

Abnormal Prp protein has two amino acids replaced which makes the protein to promote refolding of native Prp protein into diseased state(misfold).Therefore right answer is option c.Option a is wrong because abnormal Prp protein promotes misfolding of other Prp proteins only.Option b and d are wrong because abnormal Prp protein does not have a highly different secondary or primary structure.