pKa perturbations: A water-soluble globular protein has 2 aspartic acid residues in different parts of the...
pKa perturbations: A water-soluble globular protein has 2 aspartic acid residues in different parts of the tertiary structure. Both are almost completely buried in the interior of the native protein.
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(10 points) The first Asp residue has a pKa of 7.4 in the native state, but a pKa of 4.4 in the denatured state. Explain the difference in pKa between the two states
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(10 points) The other Asp residue, also buried in the native structure, has a pKa of 2.4 in the native state. Explain how this might be possible.
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pKa perturbations: A water-soluble globular protein has 2
aspartic acid residues in different parts of the...
10. The peptide shown has the amino acid sequence: A. Val-Ser-Ile-Glu-Lys B. Lys-Glu-Ile-Ser-Val C. Thr-Asp-Leu-Gln-Arg D....
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