Question

Choose the true statements about amyloid fibrils.

1. Proteins that form amyloid fibrils are normally soluble.

2. Amyloid fibrils have a high amount of α-helical structure.

3. Because most newly synthesized proteins fold correctly, the accumulation of misfolded proteins (or fragments) tends to occur slowly, thus explaining the slow onset of disease.

4. Some amyloid fibrils are formed from proteolytic fragments that self-assemble into extended β-sheet structures.

5. Proteins that convert to an amyloid structure form soluble fibrils.

Can someone help me solve this problem and explain to me why the answers are what they are please?

Answer 1

The correct statement s about amyloid protein is :

1. Proteins forming amyloid fibrils are generally soluble in nature.

2. Amyloid fibrils are consisting of high amount of alpha helical structures.

3. Accumulation of midfielder proteins occurs slowly because of correct folding of newly synthesized proteins.

5. Proteins converted to amyloid structures are soluble in nature.