Question

Part C - Resistance Phase

Lisinopril is a drug that directly blocks angiotensin-converting enzyme (ACE), leading to lower levels of the mineralocorticoid, aldosterone. What is the expected result from taking this drug?

1. Lowered blood pressure
2. Increased glucose conservation
3. Mobilization of energy reserves
4. Increased mental alertness

Answer 1

The correct answer is A.

As the hormone, Angiotensin is involved in vasoconstriction (decreasing the diameter of blood vessels) and therefore increases the blood pressure.

Angiotensin is also involved in release of Aldosterone from the Adrenal cortex which in return is involved in sodium absorption.

So, expected result of taking Lisinopril would be Lowered blood pressure,lower sodium absorption and more water will be excreted in the form of urine.

There will be no effect on glucose metabolism or energy reserves as none of the hormone is involved in glucose uptake or breakdown.

Low sodium absorption in no way is related to increased mental alertness.