Question

a. Describe how feedback inhibition is used in regulation. Name 2 enzymes in 2 different pathways...

a. Describe how feedback inhibition is used in regulation. Name 2 enzymes in 2 different pathways regulated by feedback inhibition.

b. What enzymes are responsible for synthesizing and degrading fructose 2,6-bisphosphate? How is fructose 2,6-bisphosphate used as a regulatory molecule?

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Answer #1

a.Feed back inhibition is a technique in which the product formed by the enzymatic pathway will it self blocks the activity of the enzyme involved in its biosynthesis.

1.Heme biosynthesis: inhibition of ALA synthase by Heme

2.production of estrogen and progesteron: Inhibition of LH and FSH by estrogen and progesteron by pitutary gland

b.synthesis :phosphofructokinase

Degradation:fructose 2-6 bisphosphatase

Fructose 2-6 bis phosphate elevates the level of PFK1 which is required for the process of glycolysis and it also inhibits the enzyme fructose bisphosphatase which is required for gluconeogenesis there by allows to maintain a balance. So that both glycolysis and gluconeogenesis will not takes place in the same cell there by avoiding futile cycle

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