Question

The parameter used to characterized the in vivo kinetic behavior of an exogenous compound:

function of time

biological half-life

logarithm of concentration

terminal slope

If the acid dissociation constant K_a 10^-8, then the pK_a is:

.008

8.0

.000008

.08

Answer 1

Answer part a) Biological half-life

Kinetic behavior of an exogenous compound can be study by one compartment open model (the simplest kinetic model). The biological half-life calculated by terminal slope of the plot between natural log of concentration in the compartment versus time as function of time.

Answer part b)

pKa is 8.0

solution: we know,

pKa = - log (Ka)

given, Ka = 10^-8

hence pKa = - log 10^-8

          pKa = -(-8) = 8.0