Predict the effect on cell growth of a Sos mutation that decreased its affinity for Ras.
Predict the effect on cell growth of a Sos mutation that decreased its affinity for Ras.
Homework Answers
Cell will not move from G0 phase to G1. When SOS binds with Ras , there is replacement of GDP with GTP on Ras , and Ras becomes activated and performs signalling cascade in order to activate the genes for CDK and Cyclins.
Mutated sos lacks affinity for Ras, thus Ras would not get activated.
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Predict the effect on cell growth of a Sos mutation that
decreased its affinity for Ras.
2. The following is a description of a signaling pathway initiated by receptor tyrosine kinases. Ligand → RTK → Sos → Ras → Raf → MEK → ERK → Transcription factor → Cell growth A. (3pts) Which of the...
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Classes 7-8 Cytoplasmic Growth Signaling Be able to describe Ras structure and function. What kind of protein is it? How is it regulated (Fig. 5.30)? How many forms of Ras do humans express? Be able to describe how Ras interacts with multiple downstream partners. What mechanisms render ras oncogenic? Also, how does Ras become oncogenic in the absence of ras mutations? Be able to describe how Ras interacts with the growth factor receptor signaling machinery. How did fly genetics help...
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Pls give short answers. Thank you
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