Question

DISORDER	UNDERLYING ABNORMALITY	PT TIME	APTT TIME	PLATELET COUNT	TEMPLATE BLEEDING TIME
ITP
ET
Bernard-Soulier
VWD Disease
Glanzmann
Storage pool disease
Hemophilia A
Factor X Deficiency

For each of the listed disorders, fill in the following data in the table below.

1. The specific molecular/cellular abnormalities that underlie the disorder.
2. The expected diagnostic results of PT time, APTT time, Platelet count, and Template bleeding time as either: Normal (N), Increased (I), or Decreased (D).

Answer 1

Normal range

Platelet count = 1.5-4.5 lac/mm³ PT time = 9 to 14 seconds   

APTT time= 35 to 45 seconds   Bleeding time = 2 to 6 minutes

Disorder	Underlying abnormality	PT time	APTT time	Platelet Count	Template Bleeding time
ITP	Normally blood does not clot (immune system produce the antibodies against the platelets)	Normal	Prolong	Very low	Prolong
ET	Megakaryocytic metaplasia ( megakaryocytes produce more platelets)	Normal	Prolong	High	Prolong
Bernard Soulier	Due to deficiency of glycoprotein Ib (GPIb), the receptor for binding of blood clotting factor-VIII	Normal	Prolong	Low	Prolong
VWD Disease	Lack of blood clotting factor- VIII (von Willebrand factor (VWF)	Normal	Normal to prolong	Normal	Prolong
Glanzmann	Due to deficiency of glycoprotein IIb (GpIIb/IIIa) a receptor for fibrinogen	Normal	Prolong	Normal	Prolong
Storage pool disease	Platelet granules are affected	Normal	Prolong	Below or normal	Prolong
Hemophilia- A	Due to genetic deficiency in clotting factor VIII	Normal	Prolong	Normal	Normal
Factor-X deficiency	Lack or deficiency of blood clotting factor-X in the blood circulation	Prolong	Prolong	Normal	Prolong