Question

1. In order to impact cell differentiation and proliferation, the insulin receptor substrate 1 must be phosphorylated on a _________ residue and directly bind to __________.

1. serine; growth factor receptor-bound protein 2
2. tyrosine; growth factor receptor-bound protein 10
3. serine; growth factor receptor-bound protein 10
4. tyrosine; growth factor receptor-bound protein 2

2. What is the name of the enzyme cascade that leads to cell proliferation and differentiation?

1. Phosphatidylinositol pathway
2. Mitogen pathway
3. MAPK pathway
4. Insulin mitogen pathway

3. A comparison of the insulin signaling pathway in Homo sapiens, Alligator mississppiensis, and Falco cherrug indicates that this pathway is _____ conserved, with the exception of factors associated with ________ in the American alligator.

1. highly; antiapoptosis
2. not highly; antiapoptosis
3. highly; apoptosis
4. not highly; apoptosis

4. In the signaling pathway initiated by pheromones, which gene name refers to a G protein?

1. Ste2
2. Ste20
3. Gpa1
4. Rho1

5. Which protein factor is found in the nucleus?

1. Ste2
2. Ste5
3. Ste7
4. Ste12

6. Which yeast protein is the MAP kinase kinase kinase?

1. Ste2
2. Ste5
3. Ste7
4. Ste11

7. After pheromone excitation, yeast mating is initiated by _________ of ________ by the mitogen-activated serine/threonine-protein kinase.

1. phosphorylation; Ste12
2. dephosphorylation; Ste12
3. phosphorylation; Dig1,2
4. dephosphorylation; Dig1,2

8. According the MAPK pathway for yeast, which transcription factor is involved in responses to pheromones and starvation?

1. Tec1
2. Ste5
3. Cdc42
4. Ste12

Answer 1

1 (d) tyrosine; growth factor receptor bound protein 2

2 (c) M APK kinase signalling pathway yeast

3 (c) highly; apoptosis( KEGG pathway)

4 (A) Ste2 (alpha factor pheromone receptor)

5 (d) ste12 is localised in nucleus and functions as a transcriptional activator they are transcription factors basically found in the fungi Kingdom

6 (a)ste2

7 (a) phosphorylation S Te 12

8 (b) ste5 in pheromone response pathway scaffold protein St E5 binds to other protein