Unlike polysaccharides such as glycogen or cellulose, glycosaminoglycans(GAGs) are highly negatively charged. What is the source...
Unlike polysaccharides such as glycogen or cellulose, glycosaminoglycans(GAGs) are highly negatively charged. What is the source and function of this negative charge?
Homework Answers
Glycosaminoglycans are important component of extracellular matrix in animal cell. They are made up of repeating unit of disaccharide. They are highly negatively charged due to the prevalence of acidic groups like sulphate, carboxyl, hydroxyl etc.
The main function of extracellular matrix is to help the cell maintain its shape and provide structural support to the cell. This can only be done if extracellular matrix is turgid in nature. This turgidity is provided by binding of positively charged ions to negatively charged glycosaminoglycans and this is the reason the latter is highly negatively charged. Higher the number of negatively charged ions in glycosaminoglycans, higher will be its ability to bind to positively charged ions and therefore greater will be the turgidity of extracellular matrix. The negative charge also help to bind and sequester proteins inside extracellular matrix.
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