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Explain the mechanism of leaky ribosomal scanning.

Explain the mechanism of leaky ribosomal scanning.

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Leaky scanning is a phenomenon in which a weak initiation codon triplet on mRNA is sometimes skipped by ribosome in translation initiation. The 40S ribosomal subunit continues scanning to further initiation codon. The weak initiation codon can be an ACG, or an ATG in a weak Kozak consensus context. This means that If upstream start codons are in a sequence context which is a poor match for the Kozak consensus A/GCCATGG then a proportion of scanning complexes may fail to initiate at the AUG and continue scanning to the next AUG. This is known as leaky scanning.

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