Question

You identify a mutant flippase that moves all inositol phospholipids (like PIP2, for example) to the extracellular side of the membrane. For each of the following responses, determine whether the response would proceed as normal or be inhibited in cells containing the rogue flippase. (please just write PROCEED or INHIBIT for you answer).

a. Inflammation responses that are mediated by activation of PKA.
b. Muscle contractions that require activation of calmodulin.
c. Cell cycle stimulation that requires Ras/MAPK signaling.
d. Anti-apoptosis (survival) stimuli that are triggered by PKB/Akt

Answer 1