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If 14C-labeled acetyl CoA is added to isolated mitochondria, is 14C-labeled CO2 released in the first...

  1. If 14C-labeled acetyl CoA is added to isolated mitochondria, is 14C-labeled CO2

released in the first full cycle of the citric acid cycle? Explain your answer.

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Answer #1

No, in the first cycle, the CO2 will be released from oxaloacetate molecules, one CO2 will be released while conversion of isocitrate to alpha- glutarate and one will be from alpha-glutarate to succinyl coA. The 14C- of acetyl coA will remain same till the last step of citric acid cycle.

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