Answer the following questions about paralysis: What is the general definition of paralysis? Describe the type...
Answer the following questions about paralysis:
- What is the general definition of paralysis?
- Describe the type of paralysis that may occur in the case of tetanus AND explain exactly how this condition affects the neuromuscular junction (Describe the biochemistry).
- Describe the type of paralysis that may occur in the case of botulism AND explain exactly how this condition affects the neuromuscular junction. (Describe the biochemistry)
Note: Tetanus and botulism cause two very different types of paralysis and therefore how they affect the neuromuscular junction is also different. This should be reflected in your answers.
Homework Answers
The difference between Tt and BoT is that the tetanus toxin acts on the interneurons present in the spinal cord. So there is no inhibition of the firings of the alpha-motor neurons. This in turn causes continuous contraction of the muscle.
But the botulinum toxin acts at the site of the NM junction itself and hence the muscle can't contract, causing flaccid paralysis.
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