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how do phospholipases and phosphotases regulate signal transduction?

how do phospholipases and phosphotases regulate signal transduction?
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Phospholipases and phosphotases both play an important role in the signal transduction. Phospholipases , specifically phospholipase C is catalyze the conversion of PIP(phosphatidylinositol) that is present in plasma membrane component, into DAG and IP3. Both ths DAG and IP3 act as an important second messanger in case of signal transduction and these molecule mediate the effect of first messanger in case of signal transduction. Therefore, phospholipases help to activate second messanger that carry informatio from the receptor present in cell membrane to the nucleus of the cell.

On the other, phosphotases are the enzyme that remove phosphate group from the molecule. This enzyme help in the corrdination with kinase enzyme in signal tranduction. The ligands having that are attach to the receptor protein and phosphotases mediate the transduction of these messages from receptor to ths nucleus.

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