The ____ of pyruvate to acetyl Co-A is catalyzed by ____.
a.) oxidative decarboxylation; pyruvate dehydrogenase complex
b.) dehydration; pyruvate dehydration complex
c.) decarboxylation; pyruvate decarboxylase
d.) none of the above
Answer- a) Oxidative decarboxylation; Pyruvate dehydrogenase complex.
Explanation- Pyruvate is converted to acteyl Co-A and this is mediated by Pyruvate dehydrogenase complex and Carbon Dioxide, NADH is also produced along with Acteyl Co-A. This is the link step between glycolysis and Krebs cycle.
The ____ of pyruvate to acetyl Co-A is catalyzed by ____. a.) oxidative decarboxylation; pyruvate dehydrogenase...
I1. Mammals lack the enzyme a. Lactate dehydrogenase b. Pyruvate kinase Alcohol Dehydrogenase c. d. Pyruvate decarboxylase None of the above are correct e. 12. The first reaction of the Krebs cycle combines Oxaloacetate and Acetyl CoA to make Citrate b. a. Malate and NADH to make Citrate a-ketoglutarate and citrate to make CO2 d. c- Succinate and Citrate to make Oxaloacetate 13. The electrons held by NADH and FADH, are donated to the which complexes in the ETC respectively?...
Options for each are lactate, alanine, acetaldehyde,
oxaloacetate, and acetyl-CoA.
Match the following showing reaction products of pyruvate: a) Decarboxylation by pyruvate decarboxylase b) Carboxylation c) Transamination d) Reduction e) Decarboxylation by pyruvate dehydrogenase
15. Genetic defect in pyruvate dehydrogenase complex lead a. maple syrup urine disease b. phenyike d. lactic acidemia e. pellagra syrup urine disease b, phenylketonuria c. galactosemia 10. Chemical modification by phosphorylation of pyruvate dehydros a. deactivates the enzyme b. activates the enzyme lation of pyruvate dehydrogenase complex : 17. Pyruvate carboxylase is positively ated through the allosteric mechanism by : a. ATP b. NADH c. Acetyl-SCOA d. TPP e. Biotin 18. Which of the listed coenzymes does not particip...
The step in metabolism that converts pyruvate to acetyl-CoA involves pyruvate dehydrogenase complex is shown. NADH NAD Correm A CEO CH co G Pyruvate AwA What is true about this step? ATP is required but not shown The enzyme is a multi-enzyme complex involving TPP. It requires O2 It is an easily reversible reaction
(5 points): The alpha-ketogluterate dehydrogenase complex uses three proteins and 5 different co-factors to convert pyruvate to acetyl-CoA. Identify these three proteins and five co-factors and describe the chemical role that each plays in the reaction mechanism of the a-KGDH complex. Write the balanced equation for the overall reaction catalyzed by this enzyme.
1. The pyruvate dehydrogenase complex converts pyruvate to acetyl-CoA. What are the steps that pyruvate undergoes? Which coenzymes are involved in each step? 2. Mitochondrial extracts from pigeon breast muscle were incubated with Experiment 1: Amytal, an inhibitor of complex I Experiment 2: Malonate, a competitive inhibitor of succinate dehydrogenase Which experiment will yield more ATP when the cycle is primed with intermediates?
Which of the following would not be consistent with the pyruvate dehydrogenase complex? aGeneration of NADH and acetyl CoA b. Inhibition of the complex by pyruvate dehydrogenase phosphatase C. Inhibition by acetyl CoA, NADH, and ATP d. Stimulation by phosphoenolpyruvate
1. Select the TRUE statement about the citric acid cycle. A. Isocitrate dehydrogenase is a multienzyme complex that is very similar to the pyruvate dehydrogenase complex B. The two decarboxylation steps occur right after each other, first via oxidative alpha- decarboxylation, then via oxidative beta- decarboxylation. C. In one turn of the cycle, the two carbons that enter the cycle as acetyl CoA are the same two carbons that are released as CO2. D. A flavin containing dehydrogenase enzymes oxidizes...
1.Predict the effect of a large amount of acetyl-CoA on the activity of pyruvate dehydrogenase and the rate of glycolysis. Note: pyruvate dehydrogenase is the enzyme that catalyzes the formation of acetyl-CoA from pyruvate. a. Pyruvate dehydrogenase activity will decrease while the rate of glycolysis will increase. b. Both pyruvate dehydrogenase activity and the rate of glycolysis will decrease. c. Pyruvate dehydrogenase activity will increase while the rate of glycolysis will decrease. d. The rate of glycolysis will increase, thereby,...
Write out the reaction catalyzed by the E2 enzymatic component of the pyruvate dehydrogenase complex. Describe the specific role of each cofactor in this reaction.