1. Define/differentiate the following from one another: Motif, Domain, Multi-domain, Quaternary structure
2. Define the following domains: SH2, SH3, Bromo, Chromo, PTB, SNARE, EF-Hand
3. Why are eukaryotic proteins on average bigger than prokaryotic proteins?
4. What is the role of protein domains, and why do most proteins contain more than one domain?
Answer for question no 1)
Motif - A particular arrangement of amino acids or secondary structure that can be found in other proteins can be called a motif.
Domain - A domain means the tertiary structure which can function, evolve and exist independently. This is the conserved part of the protein sequence.
Multi-domain - Multi domain means, (more than one domain) simple proteins normally contain only one or two domains, whereas larger proteins may have incorporated more than 30 domains needed for the more complex cellular functions.
Quaternary Structure - The quaternary structure of a protein is the association of several protein chains or subunits into a closely packed arrangement. Each of the subunits has its own primary, secondary, and tertiary structure.
Answer for question no 1)
Motif - A particular arrangement of amino acids or secondary structure that can be found in other proteins can be called a motif.
Domain - A domain means the tertiary structure which can function, evolve and exist independently. This is the conserved part of the protein sequence.
Multi-domain - Multi domain means, (more than one domain) simple proteins normally contain only one or two domains, whereas larger proteins may have incorporated more than 30 domains needed for the more complex cellular functions.
Quaternary Structure - The quaternary structure of a protein is the association of several protein chains or subunits into a closely packed arrangement. Each of the subunits has its own primary, secondary, and tertiary structure.
1. Define/differentiate the following from one another: Motif, Domain, Multi-domain, Quaternary structure 2. Define the following...
Define leucine zipper, helix-turn-helix, helix-loop-helix, and zinc finger, and explain why each is stable. Define the following domains: SH2, SH3, Bromo, Chromo, PTB, SNARE, EF-Hand?
Answer the following questions please: 1) What factors contribute to tertiary structure stability? Give specific examples of the bonds involved, and which one is most important. 2) Define leucine zipper, helix-turn-helix, helix-loop-helix, and zinc finger, and explain why each is stable. 3) What is alpha-helix supercoiling, and why is it so favorable? 4) Why are quaternary structures so important to cell function? 5) Define the following domains: SH2, SH3, Bromo, Chromo, PTB, SNARE, EF-Hand?