Question

Polycystic kidney (PK) disease in cats is an autosomal dominant disease that can lead to kidney failure and is usually not a problem until after cats are of breeding age or older. The gene that causes the disease is closely linked to 2 genetic markers on the same chromosome. The marker upstream of the disease gene is called the B locus and has four possible alleles: B1, B2, B3 and B4. The downstream marker is called the T locus and has 5 possible alleles: T1, T2, T3, T4 and T5. Mrs. Fiddlestix is worried that her prized Persian kitten, Fifi, may carry the disease gene because her sire, Phishy, recently died from the condition. Her dam, Coco, does not appear to have the disease and has no family history of the condition. Phishy also sired two other cats with another female (Boodles). One of the cats from that litter, Gretel (female), has the disease and the other cat, Hansel (male), shows no signs of the condition. Mrs. Fiddlestix had all the living cats genotyped at the B and T loci and has asked you to help her interpret the results. The genotypes for each individual are given below: Fifi: B1B4 T2T4 Coco: B1B3 T1T2 Gretel: B1B2 T1T3 Hansel: B1B4 T4T5 Boodles: B1B1 T1T5

a. Draw the pedigree, remembering to label all generations and individuals within each generation as learned in this class.

b. Assume there is no crossing over between the B, T and PK loci. Does Fifi carry the gene that causes the PK disease? Explain why or why not.

c. Draw the arrangement of the alleles for all members of the pedigree using CORRECT NOTATION

Answer 1

Answer:                     This question i have to write pointwise,because it's easy to understand you....

• The given condition is an autosomal dominant disease. In this condition, 50% of progeny will be affected and 50 % of the population will be normal.
• The gene that causes the disease has two markers, namely B and T.
• The possible alleles of maker B are, B2, B3 and B4 and the possible alleles of T are T1, T2, T3, T4 and T5.

b):

• If the cat’s genotype contains B2 and T3 alleles then those cats will have the Pk diseases.
• If there is no recombination and crossing over, then the alleles do not exchange and there will be no diseases in the new progeny.
• So, Fifi do not carrying the gene that causes the PK disease.

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