Why can't a S/T kinase phosphorylate Y and why can't a Y kinase phosphorylate S? A....
Why can't a S/T kinase phosphorylate Y and why can't a Y kinase phosphorylate S?
A. Y is too large to fit into the shallow cleft of an S/T kinase and S is too short to contact the γ phosphate of ATP in the deep cleft of a Y kinase.
B. Y is too short to fit into the deep cleft of a S/T kinase and S is too large to contact the γ phosphate of ATP in the shallow cleft of a Y kinase.
Homework Answers
Look at the structure of serine/threonine and tyrosine. Tyrosine has an benzene ring in side chain and is an aromatic amino acids. This make tyrosine bulkier than the serine and threonine. This prevents the Y to fit into shallow cleft of an S/T by steric hindrance. Rest of the structure of is almost same between the S/T and Y.
So option A, (Y is too large to fit into the shallow cleft of S/T kinase and S is too short to contact the Y phosphate of ATP in deep cleft of Y kinase) is the correct answer.
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in
2-3 sentences on why it is the correct answer for each,
thank you !
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