Question

In a study using electronic health records, 40 patients diagnosed as having dengue fever were

recruited along with 40 patients with non dengue

febrile illness who were matched for age, sex,

and race to the dengue patients. To determine if fasting is associated with clinical dengue,

hospital charts were then reviewed to determine whether these patients also fasted prior to their

illness. What epidemiologic study design is described here?

In screening, if people who are screened appear to have better survival outcomes only because

the disease was identified earlier, but not because death was delayed, this is what type of bias?

You are conducting your own study and decide to review some of the measurement logs with

your research assistant. You discover that the research assistant used the wrong threshold to

classify participants as having preclinical disease, what type of bias?

Answer 1

A retrospective cohort study determine dengue associated febrile illness among dengue patients using EHR..To find fasting associated with clinical dengue hospital charts were reviewed..they conducted univariable analysis and multivariable logistic regression analysis to find severity of dengue by predictive model..This cohort consist of confirmed dengue patients who evaluated for severe dengue..They included age and sex in this model and symptoms associated with dengue to find the severity of dengue..
Publication bias used early identification of disease,but not because of death was delayed..it has little impact on the result..this research process connect between independent variable and dependent variable..This analysis is based on simple statistical reasoning explained..due to research assistant wrong threshold false negative conclusion discovered ,this bias due to lack of power it included only small sample..negative publication may not solve the publication bias problem..