Question

Which of the following is the most likely reason that HIV-infected people with heterozygous HLA loci have a delayed progression to AIDS compared with individuals who are homozygous at one or more HLA loci?

Group of answer choices:

A.Formation of the membrane attack complex is less efficient when there is less allelic polymorphism present

B.A greater variety of HLA allotypes provides for presentation of a wider variety of HIV-derived peptides to CD8+ T cells

C.Phagocytosis is more efficient when a greater variety of HLA allotypes are expressed

D.Loading of processed peptides into MHC Class II molecules is less efficient when HLA loci are homozygous

E.The immunoproteasome does not function efficiently to produce antigenic peptides when the same alleles are present at all loci

Answer 1