In SN2 reactions, the stereochemistry inverts only for the chiral carbon involved in the reaction or...
In SN2 reactions, the stereochemistry inverts only for the chiral carbon involved in the reaction or for the whole molecule?
I mean, if we have a dichiral molecule in SN2 reaction, the product will be an enantiomer or a diastereomer?
Homework Answers
Solution:
In SN2 reaction, the steochemistry is inverted only on that chiral carbon where the nucleophile attack from backside to remove leaving group. The other chiral or stereocenter does not involve in this mechanism.
For example: if a compound is (1R, 2S) and nucleophile attack at chiral center 2, then:
(1R,2S ) compound is converted into (1R, 2R).
Therefore, the product is always diastereomers.
Add Answer to:
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Stereochemistry of the Su2 reaction In the Sn2 reaction the tetrahedral carbon center is inverted. We describe the mechanism as nudeophilic (Nuc) back side attack; the leaving group (LG) is leav ing from the front side. Generally, the LG and the Nucare electron rich so it would be unfavorable for them to react from the same side (charge repuls ion). The geometry of the carbon at the transition state is trigonal planar. 14) Label the 2-bromobuta...
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