Describe how the lysosomal enzymes are sorted from ER to the endosome; describe how the cells...
Describe how the lysosomal enzymes are sorted from ER to the endosome; describe how the cells make sure the enzymes are only active when they are arrived in the late endosome; also describe how the lysosome membrane proteins and lipids are protected from the lysosomal enzymes
Homework Answers
Lysosomal enzymes are sorted from Endoplasmic reticulum to the endosome in two ways namely:
- Manose-6-phasphate (M6P) dependent: in this medium soluble acid hydrolases are transported from the (M6P) receptor present in the Trans Golgi region by the (M6P) residues in to the endosome.
- Manose-6-phasphate (M6P) independent: in this medium non enzymatic proteins and the other soluble enzymes are transported to the lysosome by other receptors with the help of the membrane protein sortilin.
The cells make sure that the enzymes are active only when they arrive at the late endosome is with help few signal transductions and also phosphorylation.
The lysosome membrane proteins and lipids are protected from the lysosomal enzymes as its membrane is heavily glycosylated it can withstand the high pH within the endosome.
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