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NSAIDS have 7 categories which are some that block the NFkB pathway, some for COX-1, and...


NSAIDS have 7 categories which are some that block the NFkB pathway, some for COX-1, and some foir COX-2. Can blockade of inflammatory pathway prevent cancer? If so, wich arm of the inflammatory pathway should one focus on?
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Answer #1
  • Yes, blockage of inflammatory pathway prevent cancer.
  • So, Cox-2 inflammatory pathway should be focus.
  • According to clinical studies Cox-2 inhibitors prevents cancer.
  • Mainly highly selective Cyclooxygenase inhibitors(Cox-2) prevents cancer,(Eg: Celecoxib).
  • They restore nomal apoptosis human adenomatus colorectal polyps and also they inhibit angiogenesis.
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