Question

10) TNF and IL-1 share many overlapping functions, EXCEPT: (2 pts)

A) Induce selectin expression on endothelial cells

B) Induce NF-kB activation

C) Promote the fever response

D) Increase production of leukocytes in the bone marrow

E) Induce the wasting (catabolism) of muscle and fat

11) Which of the following will occur if selectins are not expressed on leukocytes? (2 pts)

A) Leukocytes can roll, but cannot stop or migrate across the epithelial lining

B) Leukocytes cannot roll, stop or migrate across the epithelial lining

C) Leukocytes can roll and stop, but cannot migrate across the epithelial lining

D) Leukocytes can roll, stop, and migrate across the epithelial lining

E) Leukocytes cannot roll, but can stop and migrate across the epithelial lining

Answer 1

Answer 10

The correct option is : a)  Induce selectin expression on endothelial cells

During inflammation, E-selectin plays an important role in the recruitment of leukocytes to the lesion site. Local release of IL-1 and TNF-α cytokines by macrophages in the inflamed tissue induces over expression of E-selectin in the endothelial cells of nearby blood vessels.

Answer 11

The correct option is : e) Leukocytes cannot roll, but can stop and migrate across the epithelial lining

Leukocytes bind to the endothelium and remain stationary. After this they are able to migrate into the spaces between adjacent Endothelial Cells. These interactions are initiated by a variety of chemical mediators that are elaborated from inflamed tissue and the entire process of endothelial cell adhesion of leukocytes is regulated by the sequential activation