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what are tetracylines and how do they act to inhibit ribosomal function? how does this in...

what are tetracylines and how do they act to inhibit ribosomal function? how does this in turn inhibit cell growth?
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Answer #1

Tetracycline is an antibiotic used to treat several bacterial pathologies such as Malaria, Siphilis, and plague.
It is isolated from Streptomyces bacteria.

Mechanism of action:
Tetracycline inhibits protein synthesis by blocking the attachment of the charged aminoacyl tRNA to the A -site in the large ribosome subunit.
Thus, it inhibits the chain extension.
It can bind to both 30S and 50S subunits.
It is less effective against eukaryotic ribosomes.


Proteins are the structural and functional components in the cell. If protein synthesis is inhibited, the cell growth stops.

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