Question

1. What are the 4 types of hypersensitivity reactions? Identify and describe each.

2. How do antibodies cause tissue injury and disease? What are some examples of disease caused by IgG or IgM antibodies or immune complexes, what is their pathogenesis, and what are their principal clinical and pathologic manifestations?

3. Identify and describe the mechanisms employed by the innate immune system that permit it to distinguish between self and non-self. Explain how innate immune system reactions against self are avoided. Be prepared to describe an example that illustrates each mechanism you address.

Answer 1

The four types of hyper sensitive reactions are 1.,Allergy(immediate) type of reaction;it's mediators is IgE.

2.,Cytoxic,Which is antibody-dependent and it's mediators are IgM or IgG Complement MAC.

3.,Immune Complex disease andd it,'S mediators are IgG Complement Neutrophils.

4.,Delayed type hypersensitivity,cell mediated immune memory response,antibody-independent.

2.ans,Autoimmune diseases caused by antibodies that bind to cellular receptors,causing either excess activity or inhibition of receptor function, fall in to a special class.T cells can involved directly in inflammation or cellular destruction,and they are also required to sustain auto antibody responses.