Question

Would a dysregulated GPCR or heterotrimeric G-protein have a greater risk of causing cancer? // Upstream or further downstream regulation?

Answer 1

In this case, remember requires a high frequency of stimulus and nutrients. For example, stimulus by growth factors, hormones and other ligand molecules are required in order to maintain the high rate of proliferation. In this case, GPCR or its coupled heterotrimeric G-protein are highly important to transmit a cascade signal in order to promote a cellular response. Most of the cancer cells overexpresses on their surface a variety of receptors in order to enhance the cascade signal for cellular proliferation. This is the case of GPC Receptors. A dysregulation where the GPCR is overexpressed on the surface or the heterotrimeric G-protein gets mutated making it constantly activate will lead to cancer since both factors can influence to a elevated signaling to promote cellular proliferation. It can affect the downstream regulation since the signal will go from the membrane to the nucleus in order to activate proliferative genes.