Question

1. The excitatory CNS synapse is a cell-cell junction that recruits numerous scaffold proteins beneath the postsynaptic membrane. One property of this postsynaptic scaffold, called postsynaptic density, that enabled is isolation was that is that? (Need Answer)
   1. Resistant to denaturation by heat
   2. Readily solubilized and reconstituted using a strong detergent
   3. Resistant to solubilization with a non-ionic detergent
   4. Could be isolated by affinity chromatography
   5. None above

Answer 1

Answer:

One property of this postsynaptic scaffold, called postsynaptic density, that enabled is isolation was that is that?

1. Resistant to denaturation by heat
2. Readily solubilized and reconstituted using a strong detergent
3. Resistant to solubilization with a non-ionic detergent - Correct Option (Explanation: Postsynaptic density (PSD) that includes protein kinases, cytoskeleton proteins are resistant to solubilization with low concentration of non-ionic detergents such as Triton-X. )
4. Could be isolated by affinity chromatography
5. None above