When would you suspect that a family was passing on a mutation in the Rb gene?
When would you suspect that a family was passing on a mutation in the Rb gene?
Homework Answers
Mutation in Rb gene causes cancer in Retina , Known as a rare type of eye cancer that usually develops in early childhood typically before age of 5. In this cancer the retina is becomes very sensitive to light. In childrens retinoblastoma the disease often affects only one eye. However one out of three childrens with retinoblastoma develops cancer in both eyes . The most common first sign of retinoblastoma is visible whiteness in the pupil called cat eye reflex or leukocoria . This unusual whiteness is noticeable in dim light or on flash.
One third of retinoblastomas are hereditary . Peoples with hereditary retinoblastoma have family history of disease and they are at the risk of passing on mutated RB1 gene to the next generation . A person with hereditary retinoblastoma may inhert an altered copy of a RB1 gene from one parent or altered gene may be the result of new mutation that occurs in egg or sperm cell. When retinoblastoma is get inherited or transferred into offspring from the parents then we could state that the family is passing on a mutation in Rb gene.
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When would you suspect that a family was passing on a mutation
in the Rb gene?
Seven members in the same generation of a family have a gene mutation, but only one...
Seven members in the same generation of a family have a gene mutation, but only one of the seven has the classical disease phenotype associated with this mutation. What term would you use to describe this genetic lesion? High penetrance Dominant Low penetrance
GENE EXPRESSION PROFILE A RELATIVE EXPRESSION CYCLIN D RB E2F Information for the following problem: •...
GENE EXPRESSION PROFILE A RELATIVE EXPRESSION CYCLIN D RB E2F Information for the following problem: • CYCLIN D inhibits RB • RB inhibits E2F • E2F increases mitosis 1. Is the pattern seen in gene expression profile A consistent with cancer progression? If so, explain why you have come to that conclusion 2. If consistent with cancer progression, indicate the probable gene that is mutated, and if this represents an oncogenic or tumor suppressor mutation. In your explanation, make sure...
A mutation occurs that causes the promoter of a gene to over-express a protein. Would this...
A mutation occurs that causes the promoter of a gene to over-express a protein. Would this most likely be a gain of function or loss of function mutation? Why?
If you have a mutation in a tRNA gene that impacts the second position of the...
If you have a mutation in a tRNA gene that impacts the second position of the anticodon, how would this change the protein product being produced at the ribosome?
you grow E.coli that have a mutation in their Operator gene (O) so that the operon...
you grow E.coli that have a mutation in their Operator gene (O) so that the operon is constitutively active. what would happen when this mutant is grown in media that contains glucose, but not lactose? select all answers!! A- the repressor would change shape B- the repressor would bind the operator c- the structural genes would be transcribed D- RNA polymerase would bind the promoter
How do homologous chromosomes help prevent cancer when mutation occur in gene?
How do homologous chromosomes help prevent cancer when mutation occur in gene?
Please answer 2-5 2. Consider a gene with a particular function. Mutation X and mutation Y...
Please answer 2-5
2. Consider a gene with a particular function. Mutation X and mutation Y cach cause defects in the function of the encoded protein, yet a gene containing both mutations X and Y encodes a protein that works even better than the original protein. The odds are exceedingly small that a single mutational event will generate both mutations X and Y. Explain a simple way that an organism with a mutant gene containing both mutations X and Y...
In humans, Sickle Cell Disease is caused by a mutation in the gene encoding the beta...
In humans, Sickle Cell Disease is caused by a mutation in the gene encoding the beta subunit (Hbb) of hemoglobin, the oxygen transporting protein in the blood. The most common mutation is E6V (Glutamate6-to-Valine). If you were asked to design gene editing guide that will correct the mutation by inserting a codon for phenylalanine, what codon would most likely result in the greatest level of expression of the corrected Hbb? Briefly state why the level is likely to be highest...
A cell that is heterozygous for a nonsense mutation in a tumor suppressor gene would most...
A cell that is heterozygous for a nonsense mutation in a tumor suppressor gene would most likely: A) Group of answer choices B) grow but not divide C) have a normal cell cycle D) arrest and induce apoptosis E) have a slightly increased cell cycle and increased cell growth F) grow and divide uncontrollably Which of the following correctly describes an event that occurs during transcription: Group of answer choices A) A DNA molecule is chemically modified to become a...
A hypothetical mutation in a single gene results in a “zombie” phenotype. A normal man and...
A hypothetical mutation in a single gene results in a “zombie” phenotype. A normal man and woman have 3 children – a zombie girl, a normal girl and a normal boy. The man has a normal sister and mother but his father is a zombie. The woman has a normal brother and both her parents are normal. Diagram a pedigree of this family and determine the mode of inheritance for the zombie condition. Once you have done so, determine the...
GENE EXPRESSION PROFILE A RELATIVE EXPRESSION CYCLIN D RB E2F Information for the following problem: • CYCLIN D inhibits RB • RB inhibits E2F • E2F increases mitosis 1. Is the pattern seen in gene expression profile A consistent with cancer progression? If so, explain why you have come to that conclusion 2. If consistent with cancer progression, indicate the probable gene that is mutated, and if this represents an oncogenic or tumor suppressor mutation. In your explanation, make sure...
A mutation occurs that causes the promoter of a gene to over-express a protein. Would this most likely be a gain of function or loss of function mutation? Why?
Please answer 2-5
2. Consider a gene with a particular function. Mutation X and mutation Y cach cause defects in the function of the encoded protein, yet a gene containing both mutations X and Y encodes a protein that works even better than the original protein. The odds are exceedingly small that a single mutational event will generate both mutations X and Y. Explain a simple way that an organism with a mutant gene containing both mutations X and Y...
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