3. Let’s suppose a mutation in the glucocorticoid receptor does not prevent the binding of the...
3. Let’s suppose a mutation in the glucocorticoid receptor does not prevent the binding of the glucocorticoid hormone to the protein but prevents the ability of the receptor to activate transcription. Make a list of all the possible defects that may explain why transcription cannot be activated
Homework Answers
The transcription cannot be activated due to the following reasons-
1)The mutation migh have been in the domain of the receptor that activates RNA Pol so transcription would not be activated even if the hormone binds the recepor.
2)The mutation might have prevented the dimerization of the receptor.
3)The receptor could not travel to the nucleus if the muation would be in the nuclear localization domain.
4)The mutation might have stopped HSP 90 from being released if it was in the HSP 90 domain.
5)The receptor might not recognize glucocorticoid receptor domain if it was in the DNA binding domain.
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