Question

Using the information below, give the dose (mL) of sulphadimidine mixture that should be given to a 10 month old infant, Joe Smith, every 6 hours to treat a systemic infection?
Assume the initial dose has already been given and the child is of average weight.
Express your answer to 2 significant figures.

Product: Paediatric Sulphadimidine Mixture BPC contains 100g per 1000mL
Information from the Pharmaceutical Codex, 11th Ed
For systemic infections, sulphadimidine should be given by mouth in an initial dose of up to 3 g; the subsequent dosage should be 1 g every 4 hours or 1.5 g every 6 hours.
Infants & children usually tolerate sulphonamides better than adults. For a child of average weight the dosage is one-sixth the adult dose from 6 months to 1 year of age, one-half the adult dose from 6 to 12 years of age

Answer 1

Hey, Welcome to Chegg. I hope my answer will be of some help to you. Thank you!

In normal adult, 1.5g is given every 6 hours.

For a child of 10 month, one-sixth of adult dose is given. That means 1.5÷6 g = 0.25g is given every 6 hours.

100g is present in 1000ml

So, 0.25g will be present in (1000÷100) X 0.25 = 2.50ml

Hence, 2.5ml of sulphadimidine mixture is given every 6 hours to Joe.