Is it possible for non-dividing neuronal cells to employ the homologous recombination repairing mechanism? Why or...
Is it possible for non-dividing neuronal cells to employ the homologous recombination repairing mechanism? Why or why not?
Homework Answers
Well, the answer to this question has not been cleared properly but yes, it is possible. Neurons are the non-dividing cells so if there is any damage to the genomic content of the cell either in the nucleus or in the mitochondria, there is a tough situation for the cell to decide which repair mechanism to be used. Recently, the researcher found that the base excision repair, nucleotide excision repair mechanism, and mismatch repair mechanism are present both in the nucleus and in mitochondria but homologous recombination repair mechanism is found in only matured neuronal cells. In addition, proteins involved in the homologous recombination repair increase in expression by increasing the apoptotic stimuli in the hippocampal granule cells.
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Is it possible for non-dividing neuronal cells to employ the
homologous recombination repairing mechanism? Why or...
1) Given a plant with the genotype C/cm; Ac+/Act, where om is an unstable allele caused...
1) Given a plant with the genotype C/cm; Ac+/Act, where om is an unstable allele caused by a Ds insertion. This plant is crossed with another plant with the genotype C/cm where cm is an unstable allele caused by Ac insertion. What phenotypes would be produced (including their proportion)? Assume that Ac and c are unlinked, that the chromosome-breakage frequency is negligible, and that mutant c/C is Ac+. 2) Is it possible for non-dividing neuronal cells to employ the homologous...
Haploid yeast cells that preferentially repair double-strand breaks by homologous recombination (rather than by non-homologous end...
Haploid yeast cells that preferentially repair double-strand breaks by homologous recombination (rather than by non-homologous end joining) are especially sensitive to agents that cause double-strand breaks in DNA. If the breaks occur in the G1 phase of the cell cycle, most cells will die; however, if the breaks occur in the G2 phase, a much higher fraction of cells survive. Why do you suppose this is?
Compare and contrast non-homologous end joining and homologous recombination. What are the pros and cons of...
Compare and contrast non-homologous end joining and homologous recombination. What are the pros and cons of each?
Sort the following steps for repairing double-strand breaks by homologous recombination a) Ligation b) DNA synthesis...
Sort the following steps for repairing double-strand breaks by homologous recombination a) Ligation b) DNA synthesis using undamaged DNA as template c) DNA synthesis using original DNA as template d) Release of the invading strand e) Strand invasion f) Nuclease digestion (resection)
1. Homologous recombination can happen between non-identical DNA sequences. T/F? 2. Homologous recombination can happen in_______...
1. Homologous recombination can happen between non-identical DNA sequences. T/F? 2. Homologous recombination can happen in_______ a) meiosis b) mitosis c) both 3. Homologous recombination in meiosis has the main purpose of_____ a) DNA repair b) Creating new chromosomes c) Sealing double-stranded breaks 4. Strand invasion usually happens without enzymatic assistance. T/F? 5. When replication fork runs into a nick, it results in a_______ a) single-stranded break b) double-stranded break 6. The invading end is usually a _______ a) 3'...
q39 Question 39 0.35 pts Homologous recombination is an important mechanism in which organisms use a...
q39
Question 39 0.35 pts Homologous recombination is an important mechanism in which organisms use a "backup" copy of the DNA as a template to fix double-strand breaks without loss of genetic information. Which of the following is necessary for homologous recombination to occur? telomerase O 3 DNA strand overhangs • a short stretch of sequence similarity no DNA strand overhangs
Describe how Nucleotide Excision Repair, Homologous Recombination Repair (HRR)
Describe how Nucleotide Excision Repair, Homologous Recombination Repair (HRR), and Non-homologous End Joining (NHEJ) are beneficial for repair of damaged DNA. If you could choose between having HRR and NHEJ performed, which would you choose and why?
1. A group of non-dividing cells are irradiated with UV and then left to recover for...
1. A group of non-dividing cells are irradiated with UV and then left to recover for 2 hours arrested in G1. After two hours they are allowed to undergo a round of replication. a. After the recovery, do you expect there to be inheritable mutations present in these cells? Why or why not? b. After the single round of replication do expect both daughter cells to carry the same heritable mutation? Why or why not?
Why does meiosis only occur in diploid cells (on in cells with homologous pairs of chromosomes,...
Why does meiosis only occur in diploid cells (on in cells with homologous pairs of chromosomes, such as 4N cells)?
By what mechanism do benzodiazepines reduce neuronal excitability? Why is the combination of Vali...
By what mechanism do benzodiazepines reduce neuronal excitability? Why is the combination of Valium and alcohol (or barbiturates) worse than taking Valium alone?
1) Given a plant with the genotype C/cm; Ac+/Act, where om is an unstable allele caused by a Ds insertion. This plant is crossed with another plant with the genotype C/cm where cm is an unstable allele caused by Ac insertion. What phenotypes would be produced (including their proportion)? Assume that Ac and c are unlinked, that the chromosome-breakage frequency is negligible, and that mutant c/C is Ac+. 2) Is it possible for non-dividing neuronal cells to employ the homologous...
Haploid yeast cells that preferentially repair double-strand breaks by homologous recombination (rather than by non-homologous end joining) are especially sensitive to agents that cause double-strand breaks in DNA. If the breaks occur in the G1 phase of the cell cycle, most cells will die; however, if the breaks occur in the G2 phase, a much higher fraction of cells survive. Why do you suppose this is?
q39
Question 39 0.35 pts Homologous recombination is an important mechanism in which organisms use a "backup" copy of the DNA as a template to fix double-strand breaks without loss of genetic information. Which of the following is necessary for homologous recombination to occur? telomerase O 3 DNA strand overhangs • a short stretch of sequence similarity no DNA strand overhangs
1. A group of non-dividing cells are irradiated with UV and then left to recover for 2 hours arrested in G1. After two hours they are allowed to undergo a round of replication. a. After the recovery, do you expect there to be inheritable mutations present in these cells? Why or why not? b. After the single round of replication do expect both daughter cells to carry the same heritable mutation? Why or why not?
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