Question

Even if they don’t have the mutation, hard-hitting athletes may want to take some precautions. Perhaps taking a chemical designed to be more attractive to the basic R-groups on ß-amyloid fragments than the fragments were to each other thus preventing their aggregation. Phase III trials of such a drug (Alzheimer) in 2007 failed to show benefits in 1,000 Alzheimer’s patients. What kind of bonds in the ß-amyloid protein was Alzheimer meant to disrupt?

1. Peptide bonds
2. Hydrogen bonds
3. Non-polar covalent bonds
4. Polar covalent bonds

Answer 1

B.hydrogen bonds.

Hydrogen bonds are present in the - amyloid protein. The amyloid beta protein derived from the amyloid precursor protein(APP), in the healthy brain these frgments are broke down and eliminated but in Alzheimer is misfold and deposited insoluble plaques in the brain.