bacterial resistance to antimicrobial drugs is on the increase. using your knowledge of microbial genetics, disscuss...
bacterial resistance to antimicrobial drugs is on the increase. using your knowledge of microbial genetics, disscuss at least 2 specific cell mechanisms that would allow development of antimicrobial resistance.
Homework Answers
From evolutionary perspective, two specific cell mechanisms that will allow development of antimicrobial resistance:
i) Gene mutation associated with the mechanism of action of the compound:
In this case, a bacterial cells subset develops a mutation in genes that affect the activity of the antimicrobial drug , resulting in survival of the preserved cell in the presence of the antimicrobial molecule. The susceptible population is eliminated by the antibiotic, once a resistant mutant appears, marking the predominance of resistant bacteria.
ii) Foreign DNA coding acquisition for resistance determinants through HGT : foreign DNA material acquisition through HGT is one of the most important factor that drives the bacterial evolution and frequently held the responsibility for antimicrobial resistance.
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