The breakdown of fatty acids can generate a large amount of Acetyl-CoA. In light of this...
The breakdown of fatty acids can generate a large amount of Acetyl-CoA. In light of this and of the factors that regulate the TCA cycle, what would be the effect of fatty acid breakdown on pyruvate dehydrogenase AND on glycolysis and why is this effect advantageous to the cell when fatty acids are being broken down?
Homework Answers
Acetyl CoA is two carbon atom molecule, generated from either oxidative decarboxylation of pyruvate and the β-oxidation of fatty acids. Breakdown of fatty acid in liver mitochondria leads to generation of acetyl-CoA and act as a negative regulator of pyruvate dehydrogenase. At high ATP concentrations, oxidative phosphorylation slow down which in turn inhibit the citric acid cycle and eventually acetyl-CoA levels goes up. Elevated level of acetyl-CoA inhibits pyruvate dehydrogenase complex and activate the gluconeogenesis. Therefore, an elevated level of acetyl-CoA has negative impact of glycolysis and positive impact on gluconeogenesis. Fatty acid oxidation is only source for ATP generation in certain tissues or organ such as heart and skeletal muscle.
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The breakdown of fatty acids can
generate a large amount of Acetyl-CoA. In light of this...
1. The breakdown of fatty acids can generate a large amount of Acetyl-CoA. In light of...
1. The breakdown of fatty acids can generate a large amount of Acetyl-CoA. In light of this and of the factors that regulate the TCA cycle, what would be the effect of fatty acid breakdown on pyruvate dehydrogenase AND on glycolysis and why is this effect advantageous to the cell when fatty acids are being broken down? Fatty acid breakdown 2. For the following statement, decide whether the statement is true or false and provide a justification for your answer:...
As we will see in our discussion of lipid metabolism, fatty acid breakdown generates a large...
As we will see in our discussion of lipid metabolism, fatty acid breakdown generates a large amount of acetyl-CoA. Part A Predict the effect of a large amount of acetyl-CoA on the activity of pyruvate dehydrogenase and the rate of glycolysis. Note: pyruvate dehydrogenase is the enzyme that catalyzes the formation of acetyl-CoA from pyruvate. O Both pyruvate dehydrogenase activity and the rate of glycolysis will decrease. O The rate of glycolysis will increase, thereby, leading to an increase in...
Why does acetyl CoA, a product of fatty acid catabolism, influence the pyruvate dehydrogenase complex (PDH),...
Why does acetyl CoA, a product of fatty acid catabolism, influence the pyruvate dehydrogenase complex (PDH), a control point in carbohydrate catabolism? When fatty acid breakdown is high, ADP is low and PDH is inhibited by phosphatase activity. When fatty acid breakdown is inhibited, PDH is inhibited by acetyl CoA due to phosphatase activity. When fatty acid breakdown is high, NADH levels drop, causing an increase in E2 activity. When fatty acid breakdown is high, PDH is inhibited by acetyl...
1.Predict the effect of a large amount of acetyl-CoA on the activity of pyruvate dehydrogenase and...
1.Predict the effect of a large amount of acetyl-CoA on the activity of pyruvate dehydrogenase and the rate of glycolysis. Note: pyruvate dehydrogenase is the enzyme that catalyzes the formation of acetyl-CoA from pyruvate. a. Pyruvate dehydrogenase activity will decrease while the rate of glycolysis will increase. b. Both pyruvate dehydrogenase activity and the rate of glycolysis will decrease. c. Pyruvate dehydrogenase activity will increase while the rate of glycolysis will decrease. d. The rate of glycolysis will increase, thereby,...
Lipids can be used in catabolism. When they are broken down the fatty acid portions are...
Lipids can be used in catabolism. When they are broken down the fatty acid portions are often broken down via __________ producing ___________. Group of answer choices reductive TCA cycle; pyruvate LaTeX: \beta β -oxidation; acetyl- CoA EMP; acetyl-CoA Calvin cycle; citrate
Choose the ONE BEST answer explaining how oxaloacetate and acetyl-CoA levels are balanced to maximize flux...
Choose the ONE BEST answer explaining how oxaloacetate and acetyl-CoA levels are balanced to maximize flux through the citrate cycle when energy charge in the cell is lovw Oxaloacetate is required for mitochondrial shuttle systems, and therefore it makes sense to activate pyruvate carboxylase by ATP and inhibit it by malate. None of the answers are correct. The best way to balance the input of carbon into the citrate cycle is to regulate the production of citrate using vitamins like...
Mr. Q wants to know why he has developed a fatty liver. You would give him...
Mr. Q wants to know why he has developed a fatty liver. You would give him all of the following reasons except: a. The accumulation of the niacin coenzymes with their hydrogens and electrons slows down the TCA cycle so that pyruvate and acetyl CoA levels build up. b. The excess acetyl CoA is used to make fatty acids, which accumulate as fat in the liver. c. When the enzymes oxidize alcohol, they remove hydrogens and high energy electrons and...
Why would it be advantageous to plants to be able to get acetyl-CoA from fatty acids?...
Why would it be advantageous to plants to be able to get acetyl-CoA from fatty acids? -Fatty acids are the macromolecule most easily taken up by the roots of the plant -Plants lack the ability to synthesize carbohydrates -Energy derived from photosynthesis primarily comes in the form of fatty acids -Seeds have a limited amount of space and fatty acids are the most energy dense macromolecule
Why would it be advantageous to plants to be able to get acetyl-CoA from fatty acids?...
Why would it be advantageous to plants to be able to get acetyl-CoA from fatty acids? Plants lack the ability to synthesize carbohydrates Seeds have a limited amount of space and fatty acids are the most energy dense macromolecule Energy derived from photosynthesis primarily comes in the form of fatty acids Fatty acids are the macromolecule most easily taken up by the roots of the plant
Why would it be advantageous to plants to be able to get acetyl-CoA from fatty acids?...
Why would it be advantageous to plants to be able to get acetyl-CoA from fatty acids? Plants lack the ability to synthesize carbohydrates Seeds have a limited amount of space and fatty acids are the most energy dense macromolecule Energy derived from photosynthesis primarily comes in the form of fatty acids Fatty acids are the macromolecule most easily taken up by the roots of the plant It's apparently not B maybe?
As we will see in our discussion of lipid metabolism, fatty acid breakdown generates a large amount of acetyl-CoA. Part A Predict the effect of a large amount of acetyl-CoA on the activity of pyruvate dehydrogenase and the rate of glycolysis. Note: pyruvate dehydrogenase is the enzyme that catalyzes the formation of acetyl-CoA from pyruvate. O Both pyruvate dehydrogenase activity and the rate of glycolysis will decrease. O The rate of glycolysis will increase, thereby, leading to an increase in...
Choose the ONE BEST answer explaining how oxaloacetate and acetyl-CoA levels are balanced to maximize flux through the citrate cycle when energy charge in the cell is lovw Oxaloacetate is required for mitochondrial shuttle systems, and therefore it makes sense to activate pyruvate carboxylase by ATP and inhibit it by malate. None of the answers are correct. The best way to balance the input of carbon into the citrate cycle is to regulate the production of citrate using vitamins like...
Why would it be advantageous to plants to be able to get acetyl-CoA from fatty acids? Plants lack the ability to synthesize carbohydrates Seeds have a limited amount of space and fatty acids are the most energy dense macromolecule Energy derived from photosynthesis primarily comes in the form of fatty acids Fatty acids are the macromolecule most easily taken up by the roots of the plant
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