Describe what happens in mutant cells which: Cannot degrade M-phase cyclins Express high levels of p21...
Describe what happens in mutant cells which:
- Cannot degrade M-phase cyclins
- Express high levels of p21
- Cannot phosphorylate Rb
Homework Answers
1.) mutant cell cannot degrade M-phase cyclins-----> cell would undergo for mitosis , would not be able to exit from this phase.
2.) Express high levels of p21-- p21 is a potent inhibitor of G1 CDK , cell will remain in G1 phase only.
3.) Cannot phosphorylate Rb--- Rb inhibits E2F , DP transcription factors by binding with them , so it will supress the production of Proteins responsible for S phase, no progression of G1 to S phase.
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Describe what happens in mutant cells
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